Issue: Số 1 - Tháng 1 - 2024Hóa học - Công nghệ thực phẩm
Identification of compounds from Heterometrus laoticus (Laos forest scorpion)'s venom possessing anticoagulant activity by MS and NMR
Published: July 27, 2026
Abstract
Venomous animals possess a wide range of toxins for predation and defense. It is difficult to comprehend the exact number of venomous species or the number of toxins they produce. Several venomous animals and their toxins (from snakes, scorpions, spiders, snails, lizards, frogs, fish, and insects) have been investigated to explore their biological activities and therapeutic potential.
These toxins are reported to exhibit a variety of pharmacological activities, such as myotoxic, neurotoxic, hemolytic, platelet-aggregation inhibition, anticoagulant, inflammatory, analgesic, anticancer, and antibacterial. This study explored the therapeutic potential of animals and animal toxins possessing anticoagulant activity, especially Heterometrus laoticus (H. laoticus scorpion)’s venom, for drug development in the future.
Hoàng Ngọc Anh, Hoàng Mỹ Quỳnh Trang, Nguyễn Thị Thanh Thảo, Nguyễn Thị Thùy Trang, Phạm Nguyên Đông Yên, Võ Đỗ Minh Hoàng (2013). Tách và khảo sát các thành phần chống đông máu từ nọc bò cạp Heterometrus laoticus. Tạp chí Hóa học, 51(2AB), 520-524.
2.
Barker, L.F. (1917). The Clinical Diagnosis of Internal Diseases. JAMA, LXVIII(11), 868.
3.
Liu, Y., Jennings, N.L., Dart, A.M., and Du, X.J. (2012). Standardizing a simpler, more sensitive and accurate tail bleeding assay in mice. World J. Exp. Med., 2, 30-36.
4.
Y. Ren, H. Wu, F. Lai, M. Yang, X. Li, Y. Tang (2014). Isolation and identification of a novel anticoagulant peptide from enzymatic hydrolysates of scorpion (Buthus martensii Karsch) protein. Food Research International, 64, 931-938.
5.
N.A. Valdez-Cruz, R. Conde, F.Z. Zamudio, and L.D. Possani (2010). Chapter 16 - Anticoagulants from Scorpion Venoms. In Toxins and Hemostasis: From Bench to Bedside (pp. 255-266). USA: Springer.
6.
J. Xiong et al. (2009). Anticoagulant and antithrombotic activity of a new peptide pENW (pGlu-Asn-Trp). Journal of Pharmacy and Pharmacology, 61, 1-6.
7.
S.M. Bates & J.I. Weitz (2005). New anticoagulants: beyond heparin, low-molecular-weight heparin and warfarin. British Journal of Pharmacology, 144, 1017-1028.
8.
Farsky et al. (2005). Pro and Antiinflammatory Properties of Toxins from Animal Venoms. Current Drug Targets - Inflammation & Allergy, 4, 401-411.
9.
R.M. Kini, K.J. Clemetson, F.S. Markland, M.A. McLane, T. Morita (2010). Toxins and Hemostasis: From Bench to Bedside. USA: Springer.
10.
Adenosine (58-61-7) 1H NMR. [Online] Available at: https://www.chemicalbook.com/SpectrumEN_58-61-7_1HNMR.htm
11.
HMDB0000050. [Online] Available at: https://hmdb.ca/spectra/nmr_one_d/166516 và https://hmdb.ca/spectra/nmr_two_d/1111
12.
Adenosine (C10H13N5O4). [Online] Available at: https://bmrb.io/metabolomics/mol_summary/show_data.php?molName=adenosine&id=bmse000061
