Issue: Số 17 - Tháng 6 - 2026Hóa học - Công nghệ thực phẩm
Evaluation of the quantification process of Losartan-K in pharmaceuticals using RP-HPLC/PAD analysis
Published: July 20, 2026
Abstract
This study investigates chromatographic conditions and validates the applicability of an RP-HPLC/PAD method for quantifying Losartan-K in pharmaceutical samples, while also assessing the environmental friendliness of the analytical procedure. The results show that Losartan-K can be effectively quantified using a mobile phase of MeOH: KH₂PO₄ buffer (60:40, v/v), a flow rate of 1.4 mL/min, detection at 230 nm, and a column temperature of 40°C. The method demonstrates acceptable linearity, limit of detection (LOD), limit of quantification (LOQ), accuracy, and repeatability. Furthermore, the analytical procedure exhibits relatively good green chemistry performance based on evaluation across 12 green analytical chemistry criteria.
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